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FLASH GENE

Symbol

RAI1

contributors: mct/pgu - updated : 16-03-2011

HGNC name	retinoic acid induced 1
HGNC id	9834

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SMS , DUP17P11

Susceptibility

to schizophrenia

Variant & Polymorphism repeat	CAG repeat length associated with susceptibility to schizophrenia, maybe correlated with the age of onset in SCA2

Candidate gene	directly regulate circadian rhythms
Marker
Therapy target

ANIMAL & CELL MODELS

Rai1 haploinsufficiency represents a single-gene model of obesity with hyperphagia, abnormal fat distribution and altered hypothalamic gene expression associated with satiety, food intake, behavior and obesity