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FLASH GENE
Symbol CD2 contributors: npt/mct - updated : 01-07-2009
HGNC name CD2 molecule
HGNC id 1639
Location 1p13.1      Physical location : 117.297.085 - 117.311.850
Synonym name
  • cell differentiation antigen CD2 (p50), identified by monoclonal antibodies 9.6, T11, 35.1,M-T910
  • CD2 antigen (p50), sheep red blood cell receptor
  • CD2 antigen
  • LFA-3 receptor
  • Rosette receptor
  • T-cell surface antigen T11/Leu-5
  • lymphocyte-function antigen-2
    • Synonym symbol(s) LEU5, T11, SRBC, LFA-2, FLJ46032
    DNA
    TYPE functioning gene
    STRUCTURE 14.77 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure a 3' locus control region LCR-CD2
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1595 39.3 351 - De Jager (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/HematopoieticNK cell
    Blood/Hematopoieticthymocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus extracellular segment
  • two immunoglobulin superfamily domains
  • cytoplasmic tail containing no protein kinase as well as no phosphatase domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd2
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in antigen recognition via its role in adhesion and signal transduction
  • complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
  • receptor on T lymphocytes essential for T cell adhesion and stimulation by antigen presenting cells (APCs) (Zhu 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD58 prior antigen recognition by TCR (CD58 receptor)
  • SRBC receptor
  • LFA3 receptor
  • interacting with an adaptor protein (CDC2BP) to trigger cell adhesion
  • interaction with CD58 (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
  • with CD58 up-regulate the expression of transcription factor FOXP3P3 leading to the enhanced function of CD4(+)CD25(high) regulatory T cells that are defective in subjects with MS (De Jager 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection (Li 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS