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FLASH GENE

Symbol

CD2

contributors: npt/mct - updated : 01-07-2009

HGNC name	CD2 molecule
HGNC id	1639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p13.1      Physical location : 117.297.085 - 117.311.850
Synonym name	cell differentiation antigen CD2 (p50), identified by monoclonal antibodies 9.6, T11, 35.1,M-T910
	CD2 antigen (p50), sheep red blood cell receptor
	CD2 antigen
	LFA-3 receptor
	Rosette receptor
	T-cell surface antigen T11/Leu-5
	lymphocyte-function antigen-2
Synonym symbol(s)	LEU5, T11, SRBC, LFA-2, FLJ46032

DNA

TYPE	functioning gene
STRUCTURE	14.77 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

a 3' locus control region LCR-CD2

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CD2 5 - 1595 39.3 351 - De Jager (2009)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell Blood/Hematopoietic thymocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminus extracellular segment
	two immunoglobulin superfamily domains
	cytoplasmic tail containing no protein kinase as well as no phosphatase domains

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Cd2

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in antigen recognition via its role in adhesion and signal transduction
	complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
	receptor on T lymphocytes essential for T cell adhesion and stimulation by antigen presenting cells (APCs) (Zhu 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CD58 prior antigen recognition by TCR (CD58 receptor)
	SRBC receptor
	LFA3 receptor
	interacting with an adaptor protein (CDC2BP) to trigger cell adhesion
	interaction with CD58 (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
	with CD58 up-regulate the expression of transcription factor FOXP3P3 leading to the enhanced function of CD4(+)CD25(high) regulatory T cells that are defective in subjects with MS (De Jager 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection (Li 2008)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS