Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ODF2 contributors: mct/npt/pgu - updated : 20-04-2010
HGNC name outer dense fiber of sperm tails 2
HGNC id 8114
Location 9q34.11      Physical location : 131.218.431 - 131.263.238
Synonym name
  • cenexin 1
  • outer dense fiber of sperm tails, 84-kD
  • sperm tail structural protein
  • Synonym symbol(s) FLJ44866, MGC111096, MGC9034, ODF2/1, ODF2/2, ODF84
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 44.81 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3772 - 805 - 2007 18160784
    cenexin 1
    17 - 2298 - 638 predominant transcript of testes 2007 18160784
    - - 2475 - 824 not restricted to specific tissues 2009 19386263
  • also called cenexin 1
  • efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits PLK1 through a CDC2-dependent phospho-S796 motif within the extension
  • having a novel exon 3b encoding Cenexin specific amino acids
  • splice-generated C-terminal extension mediating unanticipated centrosomal events at distinct stages of the somatic cell cycle
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    Reproductivefemale systembreastmammary gland highly
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage round spermatids extending to about half the principal piece of tail sperm
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two leucine zipper motifs
  • part of the C-terminal coiled-coil region that is also important in centrosomal/ciliary targeting and fiber formation presumably by supporting self-association and the formation of higher-order structures
  • HOMOLOGY
    Homologene
    FAMILY
  • ODF2 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • critical component of the mature centriole of the centrosome where it locates to the distal appendages
  • in the dense fibrillar component of the nucleolus
  • basic FUNCTION
  • involved in sperm tail function and motility
  • critical centrosomal component whose C-terminal extension is required for proper recruitment of PLK1 and other components crucial for normal mitosis
  • major component of the sperm tail outer dense fibers
  • having also nucleolar function during spermatogenesis and early embryogenesis
  • may be contributing to assorted ciliopathies
  • KCNA10, ODF2, PXN specific expression patterns imply potential functional significance in the inner ear
  • cenexin modulates microtubule organization and stability to mediate spindle orientation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the filamentous structure of the sperm tail
  • component of centrosomal scaffold that preferentially associates with the appendages of the mother centrioles in somatic cells
  • major component of the sperm tail cytoskeleton and a critical component of the mature centriole of the centrosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to ODF1 in elongating spermatids
  • TCHP binds the centrosomal proteins ODF2 and NIN, which are localized at the distal to subdistal ends of the mother centriole
  • is an interaction partner of MARK4 and ODF2 localization to the centriole partially depended on MARK4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS