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FLASH GENE

Symbol

MYOM2

contributors: mct - updated : 10-06-2016

HGNC name	myomesin (M-protein) 2, 165kDa
HGNC id	7614

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p23.3      Physical location : 1.993.157 - 2.093.379
Synonym name	titin associated protein
	M-band protein
	165 kDa connectin-associated protein
Synonym symbol(s)	TTNAP, MYM2

DNA

TYPE	functioning gene
STRUCTURE	100.41 kb     37 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003970 37 - 5018 NP_003961 165 1465 - 2013 23792176

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous spinal cord       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	developing skeletal muscle fibers

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	unique terminal domain
	12 repeat domains
	five fibronectin-like domains
	three immunoglobulin-like C2 type domains

HOMOLOGY

interspecies

homolog to bovine M protein

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	major component of myofibrillar band
	expression is strongly and rapidly repressed by thyroid hormone (T3) in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding myosin, titin, light meromyosin
	DYSF interacts with CASQ1, MYOM2 and dynein in human skeletal muscle

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS