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FLASH GENE
Symbol MYOM2 contributors: mct - updated : 10-06-2016
HGNC name myomesin (M-protein) 2, 165kDa
HGNC id 7614
Location 8p23.3      Physical location : 1.993.157 - 2.093.379
Synonym name
  • titin associated protein
  • M-band protein
  • 165 kDa connectin-associated protein
  • Synonym symbol(s) TTNAP, MYM2
    DNA
    TYPE functioning gene
    STRUCTURE 100.41 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392167 8 similar to Olfactory receptor 4F3 LOC389606 8 similar to bA476I15.3 (novel protein similar to septin) LOC389700 8 similar to bA110H4.2 (similar to membrane protein) LOC392168 8 hypothetical gene supported by AK127000 LOC153561 8 hypothetical protein LOC153561 LOC169270 8p23.3 hypothetical protein LOC169270 LOC392278 8 similar to Rab coupling protein; Rab-interacting recycling protein; Rab effector protein; rab11-family interacting protein 1 FBXO25 8p23.3 F-box only protein 25 LOC392169 8 LOC392169 INM01 8p23.3 hypothetical protein INM01 LOC389607 8 hypothetical gene supported by AK128318 LOC157697 8p23.3 hypothetical protein LOC157697 LOC392170 8 similar to hypothetical protein P1295.15 LOC346910 8p23.3 similar to putative nuclear protein (4B256) LOC392171 8 similar to ENSANGP00000017949 LOC392172 8 similar to hypothetical protein LOC392173 8 similar to Proline-rich protein MP-2 precursor LOC389608 8 LOC389608 LOC392174 8 similar to stage-specific S antigen homolog DLGAP2 8p23 discs, large (Drosophila) homolog-associated protein 2 CLN8 8p23.3 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) LOC286088 8p23.3 similar to TBP-associated factor 15 isoform 1; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kD; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)- ARHGEF10 8p23 Rho guanine nucleotide exchange factor (GEF) 10 KIAA0711 8p23.3 Homo sapiens KIAA0711 gene product (KIAA0711), mRNA. LOC392175 8 similar to high molecular weight glutenin subunit x MYOM2 8p23.3 myomesin (M-protein) 2, 165kDa LOC392176 8 similar to proteoglycan core protein, cartilage - bovine (fragments) LOC392177 8 LOC392177 LOC389609 8 hypothetical gene supported by AK128880 CSMD1 8p23.2 CUB and Sushi multiple domains 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 5018 165 1465 - 2013 23792176
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing skeletal muscle fibers
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • unique terminal domain
  • 12 repeat domains
  • five fibronectin-like domains
  • three immunoglobulin-like C2 type domains
  • HOMOLOGY
    interspecies homolog to bovine M protein
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • major component of myofibrillar band
  • expression is strongly and rapidly repressed by thyroid hormone (T3) in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding myosin, titin, light meromyosin
  • DYSF interacts with CASQ1, MYOM2 and dynein in human skeletal muscle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS