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FLASH GENE

Symbol

UBE2D1

contributors: mct - updated : 31-01-2023

HGNC name	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
HGNC id	12474

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
	six transmembrane spanning segments with intracellular N and C termini and a REXXE motif ressembling a motif involved in yeast transport

HOMOLOGY

interspecies

homolog to yeast UBC4/5

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	located in recycling endosomes
	localized to the cytoplasm

basic FUNCTION	involved in the degradation of cellular proteins
	mediating the E6-AP dependent ubiquitination of TP53
	regulates DAPK3 accumulation in promyelocytic leukemia protein nuclear body (PML-NB)by interacting with DAPK3 and stimulating its ubiquitination
	catalytically active UBE2D1 is required for IRF3 activation by viral infection
	critical regulators of the stability of BIRC2 protein following destabilizing stimuli such as TNFSF12 or CD40 signalling or IAP antagonists
	promiscuous E2 enzyme with an innate preference for forming polyubiquitin chains through lysine 11 (K11), lysine 48 (K48), and lysine 63 (K63) of Ubiquitin
	BIRC2 and UBE2D1 promote K11-linked polyubiquitination of RIPK1 in TNF signalling

CELLULAR PROCESS	cell cycle
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex with UBE1, UBE2D1, UBE2DG1, CBL ubiquitination complex

INTERACTION

DNA

RNA

small molecule

protein	DAPK3-binding partner (induced ubiquitination of DAPK3)
	TRIM21 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1
	UBE2N and UBE2D1 had distinct effects on the conformational dynamics of STUB1, suggesting different roles of the STUB1-E2 interaction in the ubiquitination of substrates and interaction with chaperones
	interacting with MYLIP (MYLIP-UBE2D1 complex is an important determinant of LDLR activity)
	OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex with E2 ubiquitin (Ub)-conjugating enzymes including UBE2N and UBE2D1
	preferentially binds to the monoubiquitinated OTUB1 via UB interaction with its backside donor Ub-interacting surface
	MARCH1 likely undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with UBE2D1, regulates MARCH1 expression
	CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells, and decreased the ubiquitination activity of MYLIP by inhibition of interaction between MYLIP and UBE2D1, an E2 ubiquitin ligase
	NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach silencing of UBE2D1 inhibited cell migration in gastric cancer, decreasing ubiquitination of SMAD4

ANIMAL & CELL MODELS