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FLASH GENE
Symbol UBE2D1 contributors: mct - updated : 31-01-2023
HGNC name ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
HGNC id 12474
Location 10q21.1      Physical location : 60.094.738 - 60.130.509
Synonym name
  • stimulator of Fe transport
  • ubiquitin carrier protein
  • ubiquitin-conjugating enzyme E2-17 kDa 1
    • Synonym symbol(s) UBCH5, UBCH5a, E2(17)KB1, SFT, UBC4/5
    EC.number 6.3.2.19/ 2.3.2.24/2.3.2.23
    DNA
    TYPE functioning gene
    STRUCTURE 35.74 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2669 - 147 - 1999 10066826
    6 - 2591 - 109 - 1999 10066826
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Urinarybladder   highly
     bladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • six transmembrane spanning segments with intracellular N and C termini and a REXXE motif ressembling a motif involved in yeast transport
    • HOMOLOGY
    interspecies homolog to yeast UBC4/5
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • located in recycling endosomes
  • localized to the cytoplasm
    • basic FUNCTION
  • involved in the degradation of cellular proteins
  • mediating the E6-AP dependent ubiquitination of TP53
  • regulates DAPK3 accumulation in promyelocytic leukemia protein nuclear body (PML-NB)by interacting with DAPK3 and stimulating its ubiquitination
  • catalytically active UBE2D1 is required for IRF3 activation by viral infection
  • critical regulators of the stability of BIRC2 protein following destabilizing stimuli such as TNFSF12 or CD40 signalling or IAP antagonists
  • promiscuous E2 enzyme with an innate preference for forming polyubiquitin chains through lysine 11 (K11), lysine 48 (K48), and lysine 63 (K63) of Ubiquitin
  • BIRC2 and UBE2D1 promote K11-linked polyubiquitination of RIPK1 in TNF signalling
    • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex with UBE1, UBE2D1, UBE2DG1, CBL ubiquitination complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DAPK3-binding partner (induced ubiquitination of DAPK3)
  • TRIM21 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1
  • UBE2N and UBE2D1 had distinct effects on the conformational dynamics of STUB1, suggesting different roles of the STUB1-E2 interaction in the ubiquitination of substrates and interaction with chaperones
  • interacting with MYLIP (MYLIP-UBE2D1 complex is an important determinant of LDLR activity)
  • OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex with E2 ubiquitin (Ub)-conjugating enzymes including UBE2N and UBE2D1
  • preferentially binds to the monoubiquitinated OTUB1 via UB interaction with its backside donor Ub-interacting surface
  • MARCH1 likely undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with UBE2D1, regulates MARCH1 expression
  • CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells, and decreased the ubiquitination activity of MYLIP by inhibition of interaction between MYLIP and UBE2D1, an E2 ubiquitin ligase
  • NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    silencing of UBE2D1 inhibited cell migration in gastric cancer, decreasing ubiquitination of SMAD4
    ANIMAL & CELL MODELS