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FLASH GENE

Symbol

NRP2

contributors: mct - updated : 24-02-2017

HGNC name	neuropilin 2
HGNC id	8005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   of tubular and interstitial NRP2 protein expression in patients with focal segmental glomerulosclerosis (FSGS)(Schramek 2009) constitutional   deletion     enhances detrusor contractility following bladder outlet obstruction tumoral     --over   in renal cell carcinoma

Susceptibility

to familial early-onset generalised osteoarthritis

Variant & Polymorphism SNP	increasing the risk of familial early-onset generalised osteoarthritis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	severe impairement of developmental yolk sac and embryonic angiogenesis in double homozygotes Nrp1(-/-), Nrp2(-/-)
	Nrp2 deletion in mice leads to increased bladder smooth muscle (BSM) contraction