| basic FUNCTION
| semaphorin 3C and 3F receptor |
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implicated in repulsive axon guidance and vascular endothelial growth factor |
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can function in the absence of NRP1 to mediate endothelial tube formation in hypoxia |
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involved in the organization and fasciculation of several cranial nerves and spinal nerves |
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function as receptors for both the semaphorins and vascular endothelial growth factor |
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can function in the absence of NRP1 to mediate endothelial tube formation in hypoxia |
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important role in cancer and angiogenesis |
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cell surface receptor involved in angiogenesis and axonal guidance, has recently been shown to be a critical mediator of tumor-associated lymphangiogenesis  |
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NRP2 is a mediator of prorelaxant stimuli in SMCs, suggesting a novel function for NRP2 as a regulator of visceral smooth muscle (SM) contractility |
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NRP1 and NRP2 are receptors for guidance cues of the class 3 semaphorin (SEMA) family and are expressed in partially overlapping patterns in sympathetic neural crest (NC) cells and their progeny |
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role of NRP2 in the ipsilateral growth of midbrain dopaminergic axons |
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physiological role for NRP2 in bone homeostasis |
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SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions |
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NRP1 and NRP2 are transmembrane glycoproteins that are essential for Neural crest cells (NCCs) migration |
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NRP1, NRP2 play an essential role in coordinating NCC migration with fate specification |
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is a non-tyrosine kinase receptor frequently overexpressed in various malignancies |
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novel function of NRP2 as a regulator of endocytosis, which is enhanced in cancer cells and is often associated with increased metastatic potential and drug resistance |
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WDFY1 functioned downstream of NRP2 to promote endosome maturation, thereby influencing the endosomal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of internalized cargo |
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regulation of WDFY1 transcription by NRP2 axis is a critical event in maintaining metastatic phenotype in cancer cells |
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SEMA3A, -3C, and -3F, likely with coreceptors NRP1, NRP2, and plexin-A1 and/or -A3, promote migration and possibly other activities of human DCs during innate and adaptive immune responses |
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new role for NRP2 in the positioning of neurons during adult hippocampal neurogenesis, acting via the GSK3B signaling pathway |
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NRP1 and NRP2 are co-receptors for heparin-binding growth factors and class 3 semaphorins |
