Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CLDN4

contributors: mct - updated : 21-01-2017

HGNC name	claudin 4
HGNC id	2046

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer tumoral     --over   in ovarian carcinoma tumoral     --over   in intestinal-type gastric cancer ( lower in diffuse-type gasric cancer) tumoral     --over   in prostate cancer, highly expressed in lower grade lesions than in higher grade tumoral     --low   in highly aggressive esophageal cancer and the reduction of CLDN4 leads to the resultant disruption of tight junctions that may be associated with EMT constitutional     --over   in the placentas of diabetic mothers and in toxaemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	very useful marker for distinguishing mesothelioma and adenocarcinoma, even if histological specimens are small, as in biopsies that contain limited numbers of tumor cells
	highly specific and sensitive immunohistochemical marker for assisting in distinguishing epithelioid mesotheliomas from metastatic carcinomas to the serosal membranes (pMID: 23596113)
Therapy target
	System Type Disorder Pubmed cancer     anti-claudin-3 and -4 bispecific monoclonal antibody shows promise in the development of a diagnostic and therapeutic antibody for cancers cancer digestive colon potential markers and therapy target in colorectal cancer cancer reproductive prostate useful as a potential marker and therapeutic target for prostate cancer metastases

ANIMAL & CELL MODELS

progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia