Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP1R10 contributors: mct/ - updated : 26-03-2014
HGNC name protein phosphatase 1, regulatory subunit 10
HGNC id 9284
Location 6p21.33      Physical location : 1.861.090 - 30.585.020
Synonym name
  • gene of unknown function, highly homolog to CAT56
  • phosphatase-1 nuclear targeting subunit
  • serine/threonine-protein phosphatase 1 regulatory subunit 10
  • protein FB19
  • MHC class I region proline-rich protein CAT53
  • Synonym symbol(s) FB19, PNUTS, CAT53, p99, PPR10, R111, PP1C
    DNA
    TYPE functioning gene
    STRUCTURE 16.84 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located located within the HLA class I region, located 70kb centromeric to the HLA-E gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4540 99.1 940 - 1998 9461602
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal transcription elongation factor S-II (TFS2N) domain implicated in the transcriptional initiation or elongation of RNA polymerase (pol) II
  • a glycine-rich region followed by a domain of 35 residues
  • a PP1-binding and inhibitory domains
  • a putative zinc finger cccH type
  • a consensus PP1-binding RVXF motif
  • C-terminal RGG motifs that interact with homopolymeric RNA
  • HOMOLOGY
    intraspecies homolog to CAT56,highly
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • colocalized with chromatin at distinct phases during mitosis
  • normal association with chromosomes but causes defects in the process of chromosome decondensation at late telophase
  • predominantly localized to the interphase nucleus of mammalian cells
  • tightly associates with chromatin during interphase but is excluded from chromosomes at early mitosis and is reloaded onto chromosomes during the transition from mitosis to interphase
  • basic FUNCTION
  • targeting protein phosphatase 1 (PP1) to specific RNA-associated complexes in the nucleus
  • potently inhibiting the catalytic activity of PP1
  • may contribute to the regulation of cell viability
  • can regulate telomere length via its interaction with TERF2
  • regulates the phosphorylation and apoptotic activities of TP53 under hypoxic conditions
  • may be a regulator of signaling events promoting chromosome decondensation as cells reenter interphase
  • also implicated in regulation of cell cycle progression and apoptosis
  • potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase
  • role for PPP1R10 in the regulation of DNA repair
  • regulates POLR2A-mediated gene expression and is necessary for developmental growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein nucleus import
    PATHWAY
    metabolism
    signaling
    a component
  • stable multimeric complex composed of regulatory subunits PPP1R10, TOX4, and WDR82 , and PPP1CC catalytic subunit (denoted as the PTW/PP1 phosphatase complex)
  • new and integral component of the DNA damage response involved in DNA repair
  • INTERACTION
    DNA sDNA binding
    RNA mRNA binding
    small molecule nucleotide,
  • selective binding for poly(A) and poly(G) ribonucleotide homopolymers
  • protein
  • forming a complex with PP1
  • interacting with TERF2 via the [Y/F]XL motif
  • binds tightly to TOX4 (transcriptional activity of TOX4 is markedly suppressed by its interaction with PPP1R10, in a PP1-independent manner)
  • targets PP1 to synaptic sites, acting as a temporary bridge between the phosphatase and GABA(C) receptors
  • interact with the telomeric protein telomere repeat factor 2
  • directly interacted with the lipid-binding domain (C2 domain) of PTEN and sequestered it in the nucleus
  • cell & other
  • targeted to the reforming nuclei in telophase following the assembly of nuclear membranes and concomitantly with chromatin decondensation (may be a part of a signaling event promoting chromatin decondensation as cells re-enter interphase)
  • REGULATION
    induced by by hypoxia
    inhibited by phosphorylation by PKA, reducing the ability to bind to PP1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    leads to activation of Rb-phosphatase and caspase-mediated apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS