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FLASH GENE

Symbol

HFE

contributors: mct - updated : 24-10-2011

HGNC name	hemochromatosis
HGNC id	4886

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HFE , VGP

Susceptibility

Variant & Polymorphism SNP	HFE C282Y and H63D polymorphism inducing a variation in iron status: serum transferin saturation is more affected than is serum ferritin.

Candidate gene	for amyotrophic lateral sclerosis
Marker
Therapy target

ANIMAL & CELL MODELS

	knock-out Hfe -/- mice
	iron overload due to deletion of Tfr2 in mice is more severe than that due to Hfe, and loss of both molecules results in pronounced iron overload