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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ROBO1

contributors: mct/npt/pgu - updated : 22-05-2015

HGNC name	roundabout, axon guidance receptor, homolog 1 (Drosophila)
HGNC id	10249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     of the U-twenty-twenty cell line of small cell lung carcinoma tumoral   LOH     in breast carcinoma with promoter methylation constitutional     --low   abnormalities of ROBO1 may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment tumoral   LOH     in primary head and neck cancerous lesions tumoral       loss of function in human cancers and may regulate apoptosis and metastasis

Susceptibility

to autism

Variant & Polymorphism

Candidate gene	for susceptibility to dyslexia
	inactivation of ROBO1 could be used as molecular signature for early detection and prognosis of the head and neck cancer
Marker
Therapy target

ANIMAL & CELL MODELS

bronchial hyperplasia and dysplasia in knockout mice