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FLASH GENE
Symbol MAP4 contributors: shn - updated : 30-08-2018
HGNC name microtubule-associated protein 4
HGNC id 6862
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandem related repeats of approximatly 14 amino acods, a region with clusters of proline and serine
  • a C terminal region with three imperfect 18 amino acids repeats homolog to the MT binding domain of MAP2 and MAPT
  • four TAU/MAP repeats
    • HOMOLOGY
    interspecies ortholog to Map4, Rattus norvegicus
    ortholog to Mtap4, Mus musculus
    Homologene
    FAMILY MAP (mitogen activated protein) kinase family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • promoting microtubule assembly, and counteracting destabilization of interphase microtubule catastrophe promotion
  • involved in the regulation of microtubule stability
  • involved in microtubule network stability and microtubule network density by its phosphorylation
  • CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
  • MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
  • unexpected role of TRAF3IP1 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Cyclin B
  • physically interacts with dynein-dynactin and inhibits dynein-mediated microtubule sliding
  • MAP4, which is a binding partner of SEPT2, controls the accessibility of septins to microtubules
    • cell & other
    REGULATION
    Other phosphorylated by protein kinase p110mark
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    of exon 9 of MALT1 and exon 9 of MAP4 in diffuse large B-cell lymphoma
    tumoral fusion      
    with RAF1 in melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS