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FLASH GENE

Symbol

MAP4

contributors: shn - updated : 30-08-2018

HGNC name	microtubule-associated protein 4
HGNC id	6862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	238.59 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D3S3582 - D3S1767 - MAP4 - D3S3560 - D3S2384 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002375 (transcript variant 1) 19 splicing 6337 NP_002366 - 1152 - - NM_001134364 (transcript variant 4) 19 splicing 6046 NP_001127836 - 1135 - - NM_030885 (transcript variant 3) 4 splicing 3224 NP_112147 - 99 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately Nervous brain       highly   nerve       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Connective bone     moderately Muscular striatum skeletal   highly

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

physiological period

Text	embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	tandem related repeats of approximatly 14 amino acods, a region with clusters of proline and serine
	a C terminal region with three imperfect 18 amino acids repeats homolog to the MT binding domain of MAP2 and MAPT
	four TAU/MAP repeats

HOMOLOGY

interspecies	ortholog to Map4, Rattus norvegicus
	ortholog to Mtap4, Mus musculus

Homologene

FAMILY

MAP (mitogen activated protein) kinase family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	promoting microtubule assembly, and counteracting destabilization of interphase microtubule catastrophe promotion
	involved in the regulation of microtubule stability
	involved in microtubule network stability and microtubule network density by its phosphorylation
	CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
	MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
	unexpected role of TRAF3IP1 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	Cyclin B
	physically interacts with dynein-dynactin and inhibits dynein-mediated microtubule sliding
	MAP4, which is a binding partner of SEPT2, controls the accessibility of septins to microtubules

cell & other

REGULATION

Other

phosphorylated by protein kinase p110mark

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       of exon 9 of MALT1 and exon 9 of MAP4 in diffuse large B-cell lymphoma tumoral fusion       with RAF1 in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS