Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

VAMP8

contributors: mct/pgu - updated : 20-06-2016

HGNC name	vesicle-associated membrane protein 8 (endobrevin)
HGNC id	12647

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to early-onset myocardial infarction (MI)

Variant & Polymorphism SNP	associated with early-onset MI

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	VAMP8 null mice resulted in hydronephrosis and the level of AQP2 was increased by 3 to 5fold. VAMP8 may mediate the regulated fusion of AQP2-positive vesicles with the plasma membrane
	VAMP8 null mice display reduced adiposity with increased energy expenditure despite normal food intake and reduced spontaneous locomotor activity