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FLASH GENE
Symbol MMP17 contributors: mct - updated : 29-11-2014
HGNC name matrix metalloproteinase 17 (membrane-inserted)
HGNC id 7163
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc binding site (the cysteine switch)
  • a hinge region
  • a furin activation sequence
  • a GPI anchor domain
    • conjugated GlycoP , MetalloP
    isoforms Precursor two forms 67 and 71kDa
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • MMP17 (MT4-MMP) and MMP25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family
    • basic FUNCTION
  • membrane type 4-matrix metalloproteinase
  • involved in neurogenesis
  • implicated in the control of articular cartilage extracellular matrix aggrecan integrity in an inflammatory environment
  • key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding TIMPs in a 1:1 stoechiometry
  • SNAI2 regulated the transcription of MMP17 through direct binding to the E-box located in its proximal promoter
  • implicated in the activation of one of the key aggrecanases: ADAMTS4
  • SERPINE2 inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells
    • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS