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FLASH GENE

Symbol

MMP17

contributors: mct - updated : 29-11-2014

HGNC name	matrix metalloproteinase 17 (membrane-inserted)
HGNC id	7163

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	23.38 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	SNAI2 regulated the transcription of MMP17 through direct binding to the E-box located in its proximal promoter

MAPPING

cloned

Y

linked

status

confirmed

regionally located

linked to D12S367

RNA

TRANSCRIPTS	type	messenger

text	one minor non expressed transcript and a major alternatively spliced, 67 and 71kDa (Kajita)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016155 10 - 2427 NP_057239 67 603 - 2003 12730128 MMP17S - - - 57.8 519 - 2003 12730128

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel capillary     predominantly Homo sapiens Fetal Nervous brain       highly Reproductive female system ovary         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
	a catalytic domain with the zinc binding site (the cysteine switch)
	a hinge region
	a furin activation sequence
	a GPI anchor domain

conjugated

GlycoP , MetalloP

isoforms

Precursor

two forms 67 and 71kDa

HOMOLOGY

Homologene

FAMILY

MMP family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	MMP17 (MT4-MMP) and MMP25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family

basic FUNCTION	membrane type 4-matrix metalloproteinase
	involved in neurogenesis
	implicated in the control of articular cartilage extracellular matrix aggrecan integrity in an inflammatory environment
	key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein	binding TIMPs in a 1:1 stoechiometry
	SNAI2 regulated the transcription of MMP17 through direct binding to the E-box located in its proximal promoter
	implicated in the activation of one of the key aggrecanases: ADAMTS4
	SERPINE2 inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells

cell & other

REGULATION

activated by

furin (intracellularly) and proteinases

inhibited by

TIMPs and TFPI2

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS