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FLASH GENE
Symbol MOCS2 contributors: mct - updated : 04-05-2016
HGNC name molybdenum cofactor synthesis 2
HGNC id 7193
Corresponding disease
MOCODB molybdenum cofactor deficiency, type B
Location 5q11.2      Physical location : 52.393.896 - 52.405.598
Synonym name
  • MPT synthase
  • molybdopterin synthase
  • molybdopterin-synthase large subunit
  • molybdopterin-synthase small subunit
  • sulfur carrier protein MOCS2A
  • Synonym symbol(s) MOCO1, MPTS, MCBPE, MOCS2A
    EC.number 2.8.1.12
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text
  • transcript by a single bicistronic mRNA with overlapping reading frames
  • with the small MOCO1-A and the large MOCO1-B subunits
  • STRUCTURE 11.71 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D5S628 - MOCS2 - D5S474 - qter
    RNA
    TRANSCRIPTS type messenger
    text the small MOCO1-A and the large MOCO1-B subunits (PMID: 9889283)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1347 - 88 - 2006 16737835
  • also called MOCO1-A or MOCS2A
  • uses an alternative exon in the 5' UTR, as compared to
  • MOCSO1B, and encodes the small subunit
    7 splicing 1532 - 188 - 2006 16737835
  • also called MOCO1-B or MOCS2B
  • encodes the large subunit
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestivesalivary gland   highly
    Endocrinepancreas    
     parathyroid   highly
    Nervousbrain    
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly conserved C-terminal double glycine motif, and extension of the C terminus with an additional glycine of MOCS2 and URM1 altered the localization of MOCS3 from the cytosol to the nucleus
  • first step of activation of both MOCS2 and URM1 consists of the formation of an acyl-adenylate group at the C-terminal glycine residue
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • moaE family
  • MOCS2B subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dual localization in the cytoplasm and the nucleus
  • basic FUNCTION
  • bicistronic enzyme, catalyzing the second step of the molybdenum cofactor synthesis
  • converting precursor Z (see MOCS1) to molybdopterine
  • essential for the function of sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase enzymes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    molybdenum cofactor biosynthesis
    a component
  • heterodimer of a large and a small subunit
  • MOCS3 forms heterotetrameric complexes with both URM1 and MOCS2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both URM1 and MOCS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MOCODB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS