Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GIPC1 contributors: mct - updated : 31-08-2020
HGNC name GIPC PDZ domain containing family, member 1
HGNC id 1226
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • multiple phosphorylation sites
  • GH1 and GH2 domains
  • a central PDZ (PSD95/disc large/ZO-1) domain interacting with RGS-GAIP, directly engaged the C-terminal sequence of APPL1
  • a C terminal acyl carrier protein (ACP) domain and MYO6 binding site
    • HOMOLOGY
    interspecies homolog to rattus Gipc1 (96.4pc)
    homolog to murine Gipc1 (96.4pc)
    Homologene
    FAMILY
  • GIPC family
    • CATEGORY regulatory , antigen , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • potentially involved in the regulation of vesicular trafficking
  • regulating cell mobility
  • recruits RGS19 to attenuate dopamine D2 receptor signaling
  • might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion
  • required for both internalization of cell surface receptors and for coupling of MYO6 to uncoated endocytic vesicles
  • NMDA receptor-interacting protein, that associates with surface as well as internalized NMDA receptors when expressed in heterologous cells
  • may be preferentially associated with extrasynaptic NMDA receptors and may play a role in the organization and trafficking of this population of receptors
  • promotes SLC2A1 trafficking to the cell surface
  • scaffolding protein that regulates cell surface receptor expression and trafficking
  • involved in G protein-linked signaling
  • novel breast cancer-associated immunogenic antigen overexpressed in breast cancer
  • is involved in IGF1 signaling leading to ZNF143 expression through the regulation of ROS production, which may play a role for colon cancer tumorigenesis
  • broad role for GIPC1 in the development of both stereociliary bundles and cell polarization
  • novel role for GIPC1 as a master regulator of autophagy and the exocytotic pathways in cancer
  • regulates cellular trafficking pathways by modulating the secretion, biogenesis, and molecular composition of exosomes
  • plays a critical role in the trafficking and regulation of membrane receptor pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    IGF1 signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GAIP
  • interacting with IGF1 receptor
  • interacting with RGS19, via its C-terminal PDZ-binding motif
  • interacting with TGFBR3 (inducing increased expression of TGFB3)
  • interacting with APPL1 (GIPC1 and APPL1 play a role in NTRK1 function and suggest that a population of endosomes bearing a complex of APPL1, GIPC1, and activated NTRK1 may transmit NGF signals)
  • interacting with SLC2A1, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4, SEMA4C, HTLV-I Tax
  • interaction between TGFBR3 and GIPC1
  • GIPC1, ACVR1, BMPR1A, and TGFBR1 are signaling components required for TGFBR3-mediated endothelial cell epithelial-mesenchymal transformation
  • GIPC1 is a critical component of endoglin function during developmental angiogenesis
  • is a new interactor for VANGL2, and MYO6-GIPC1 protein complex can regulate VANGL2 traffic in heterologous cells
  • MYO6 functions in endocytosis in conjunction with binding partners including adaptor protein (TFAP2A, DAB2, and GIPC1)
  • VEGFA induced interactions between NRP1 and GIPC1, a scaffold protein, and complex formation between GIPC1 and PLEKHG5, a RhoGEF
  • interaction with PLXND1, through a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes
  • GIPC1-mediated endocytic trafficking regulates PLXND1 signaling
  • promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPDM2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in breast and ovarian cancer ,
    tumoral     --low  
    in gastric, colorectal cancer, primary kidney and prostate tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Gipc1 mutant mice show specific defects in axonal projections, as well as vascular structures, that rely on Plexin-D1 signalling for their development