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FLASH GENE
Symbol GALNS contributors: - updated : 10-05-2006
HGNC name galactosamine (N-acetyl)-6-sulfate sulfatase
HGNC id 4122
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40 and 15 kDa polypeptides, linked by disulfide bond
  • larger N terminal domain
  • smaller C terminal-monomeric form
  • a formylglycine redidue generated from cystein (active site)
    • HOMOLOGY
    Homologene
    FAMILY
  • sulfatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • acetyl-galactosamine-6-sulfate sulfatase, stepwise degradation of glycosaminoglycans (mucopolysaccharides)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with the protective protein PPGB, and NEU1
    • cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS4A
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS