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FLASH GENE
Symbol CD1E contributors: SGE/pgu - updated : 27-07-2011
HGNC name CD1e molecule
HGNC id 1638
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Lymphoid/Immunethymus   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticthymocyte
Lymphoid/Immunedendritic cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ig-like (immunoglobulin-like) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor proteolytically cleaved in late endosomes to yield a soluble form
    HOMOLOGY
    Homologene
    FAMILY
  • CD1 family of major histocompatibility (MHC)
    • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • cleaved into a soluble form found in lysosome lumen
  • LAPTM5 and CD1E colocalize in trans-Golgi and late endosomal compartments
    • basic FUNCTION
  • involved in the immune response
  • helping to expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune resposnes
  • related to the peptide-presenting MHC class I family
  • could be a pot
  • participates in the presentation of lipid antigens in dendritic cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimer with beta-2-microglobulin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of LAPTM5 with CD1E, suggesting that LAPTM5 might influence the role of CD1E in the presentation of lipid antigens
    • cell & other
    REGULATION
    Other mono-ubiquitinated, ubiquitination of CD1E appears to trigger its exit from Golgi compartments and its transport to endosomes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other one variant of CD1E with a proline at position 194, does not assist PIM(6) presentation to CD1b-restricted specific T cells, homozygous individuals might display an altered immune response to complex glycolipid Ags
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS