| basic FUNCTION
| transcriptional regulator involved in developmental processes |
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involved in the formation of the vertebral column, the ureter, and the posterior pole of the heart |
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required for the formation of the venous pole of the heart from an NKX2-5-negative precursor population |
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functions as a transcriptional repressor by forming homo- or heterodimers with other T-box proteins or with other families of transcription factors |
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directly represses the GJA1 promoter  |
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represses GJA1 transcription and thus reduces its protein level, without affecting other connexins |
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its expression recapitulates at least some cardinal features of the sinoatrial node |
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is dispensable for epicardial development, yet a repressive T-box function may be required to prevent premature smooth muscle cell differentiation by repressing transforming growth factor beta receptor and Notch signalling in the embryonic epicardium |
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potential function of Tbx18 in maintaining the progenitor status of epicardial-derived cells |
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is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney (pMID: 24727670) |
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performs a vital role in development of multiple organ systems |
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temporal suppression of TBX18 gene expression by the hypermethylation of its promoter seems to trigger the differentiation of mesenchymal cells into hypertrophic chondrocytes in the early stages of endochondral ossification |
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is essential for developmental specification of the ureteric mesenchyme and ureteric smooth muscle cells |
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TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb |
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TBX18 and other members of the T-box gene family, namely, TBX1, TBX2, TBX3, and TBX20, play additional roles in development and homeostasis of other components of the excretory system |
