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FLASH GENE
Symbol HERC1 contributors: mct - updated : 06-02-2008
HGNC name hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
HGNC id 4867
Location 15q22      Physical location : 63.900.817 - 64.126.147
Synonym name
  • guanine nucleotide exchange factor p532
  • hect domain and RCC1-like domain 1
  • Synonym symbol(s) P532, H6, GEF, p619
    DNA
    TYPE functioning gene
    STRUCTURE 226.00 kb     77 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    77 - 15216 - 4861 - Garcia-Gonzalo (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two regions of seven internal RLD repeats beta-repeat domains characteristic of the beta-subunit of heterotrimeric G proteins
  • one WD40 domain
  • three putative SH3 binding sites, seven polar amino acid-rich regions, a RCC1 domain
  • a putative leucine zipper
  • a C terminal HECT domain characteristic of E3 ubiquitin ligases
  • HOMOLOGY
    intraspecies homolog to HECT (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD)1
    Homologene
    FAMILY HERC family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in protein trafficking
  • stimulating guanine nucleotide exchange on ARF1 and Rab proteins
  • regulating cell growth through inhibition of the mammalian target of rapamycin pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a cytosolic ternary complex with clathrin and Hsp70, involved in protein trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • myristoylated ARF1 (small GTP binding protein)
  • clathrin, heavy chain, only on the cytosol
  • TSC2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS