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FLASH GENE

Symbol

SLC7A7

contributors: mct - updated : 22-04-2011

HGNC name	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
HGNC id	11065

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol   spleen       highly Digestive intestine small intestine     highly Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane segments
	cytoplasmic N and C termini
	two conserved cysteine residues between TM3 and TM4
	the first residue interacting with a cysteine in the 4F2 heavy chain

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	solute carrier family 7, cationic amino-acid
	heterodimeric amino acid transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	basolateral membrane of epithelial cells

basic FUNCTION	mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
	light chain of the heterodimeric carrier responsible for cationic amino acid (CAA) transport across the basolateral membranes of epithelial cells in intestine and kidney
	potentially a major contribution to the transport of cationic amino acids in pachytene spermatocytes and early spermatids
	GPR55 and its endogenous ligand SLC7A7 play essential roles in the homoeostatic responses to stress signals in several mammalian tissues and cells including certain types of immune cells
	role of SLC7A7 and its receptor GPR55 in cancer cells in activating an autocrine loop that regulates cell proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with the heavy chain 4F2hc, CD98 to form a complex of approximatly 135kDa, mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
	system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
	DDHD1-SLC7A7-GPR55 axis may be involved in functions in the brain (

INTERACTION

DNA

RNA

small molecule

protein	interfering with SLC7A6
	ligand of GPR55

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LPI

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel cancer biomarker
Therapy target

ANIMAL & CELL MODELS