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FLASH GENE
Symbol SOX14 contributors: - updated : 26-05-2006
HGNC name SRY (sex determining region Y)-box 14
HGNC id 11193
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain
  • a bipartite localization signal (NLS) on the N terminal domain of the HMG box
  • a transactivation domain in the carboxyl terminus (transcription activation)
    • HOMOLOGY
    interspecies homolog to murine Sox14
    homolog to C.elegans f40e10.2
    Homologene
    FAMILY class B SRY-related HMG BOX family of transcription factor
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a negative regulator of transcription
  • modulator of LINE retroposons promoter activity
  • potentially involved in regulation of nervous system development and in limb development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS