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FLASH GENE

Symbol

SOX14

contributors: - updated : 26-05-2006

HGNC name	SRY (sex determining region Y)-box 14
HGNC id	11193

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       predominantly Nervous spinal cord       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	predominantly in fetal brain,apical ectodermal ridge

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an high mobility group (HMG) domain
	a bipartite localization signal (NLS) on the N terminal domain of the HMG box
	a transactivation domain in the carboxyl terminus (transcription activation)

HOMOLOGY

interspecies	homolog to murine Sox14
	homolog to C.elegans f40e10.2

Homologene

FAMILY

class B SRY-related HMG BOX family of transcription factor

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as a negative regulator of transcription
	modulator of LINE retroposons promoter activity
	potentially involved in regulation of nervous system development and in limb development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS