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FLASH GENE
Symbol SOX14 contributors: - updated : 26-05-2006
HGNC name SRY (sex determining region Y)-box 14
HGNC id 11193
Location 3q22-q23      Physical location : 137.483.578 - 137.484.396
Synonym name HMG box transcription factor SOX-14
Synonym symbol(s) MGC119899, SOX28, SRY-box 14
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
text structure CCAAT box motif present in the promoter plays a functional role in the transcription of this gene
MAPPING cloned Y linked N status confirmed
Map pter - D3S1267 - D3S1589 - D3S1292 - D3S3641 /D3S3696 - D3S1590 - D3S1615 - D3S2453 - D3S3528 - D3S1549 - D3S3349 - D3S1576 - SOX14 - D3S3586 - RBP2 - RBP1 - D3S3554 - D3S2983 - D3S1316 - D3S1744 - cen
Authors de Baere (99), Hargrave (00), LDB (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   predominantly
Nervousspinal cord   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text predominantly in fetal brain,apical ectodermal ridge
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain
  • a bipartite localization signal (NLS) on the N terminal domain of the HMG box
  • a transactivation domain in the carboxyl terminus (transcription activation)
    • HOMOLOGY
    interspecies homolog to murine Sox14
    homolog to C.elegans f40e10.2
    Homologene
    FAMILY class B SRY-related HMG BOX family of transcription factor
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a negative regulator of transcription
  • modulator of LINE retroposons promoter activity
  • potentially involved in regulation of nervous system development and in limb development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS