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FLASH GENE

Symbol

MATN4

contributors: mct - updated : 08-06-2021

HGNC name	matrilin 4
HGNC id	6910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003833 11 splicing 2308 NP_003824 61.8 581 - 2012 22876117 three EGF-like NM_030590 8 splicing 2099 NP_085080 57.3 540 - 2012 22876117 two EGF-like NM_030592 8 splicing 1976 NP_085095 - 499 - 2012 22876117 one EGF-like NM_001393530 10 - 2222 NP_001380459 - 581 - 2012 22876117 NM_001393531 9 - 2304 NP_001380460 - 575 - 2012 22876117

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Connective cartilage       Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	kidney, lung, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	signal peptide
	two Von Willebrand factor A-like domains connected by four EGF-like domains
	a potential coiled-coil alpha helical domain

conjugated

GlycoP

mono polymer

homomer , heteromer , polymer

HOMOLOGY

interspecies

homolog to murine Matn4

Homologene

FAMILY

matrilin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	involved in the formation of filamentous networks in the extracellular matrices of various tissues
	MATN2, MATN4 have been shown in human dental pulps and might be involved in the dentin-pulp complex wound-healing process
	is an important negative regulator of the hematopoietic stem cells (HSCs) stress response
	MATN1, MATN2, MATN3, MATN4 are important to protect articular cartilage from deterioration and are involved in the specification of the vertebral column

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	major component of the extracellular matrix of cartilage
	oligomeric extracellular matrix protein

INTERACTION

DNA

RNA

small molecule

protein

link between the ECM protein MATN4 and cytokine receptor CXCR4 involved in the regulation of hematopoietic stem cells (HSCs) proliferation and expansion under acute stress

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	FBN2, TNC, MATN2, and MATN4 may be markers of the pathogenesis of either granular or lattice type I corneal dystrophy
Therapy target

ANIMAL & CELL MODELS

Matn4-/- mice developed age-associated osteoarthritis suggesting a crucial role of MATN4 in maintaining the stability of the articular cartilage