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FLASH GENE

Symbol

PTPRJ

contributors: shn/npt/pgu - updated : 08-02-2016

HGNC name	protein tyrosine phosphatase, receptor type, J
HGNC id	9673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in colorectal, lung and breast cancer. tumoral     --low   may contribute to but is not sufficient for leukemogenic cell transformation (

Susceptibility

to breast cancer

Variant & Polymorphism

Candidate gene	candidate tumor suppressor in the colon epithelium
Marker
Therapy target	upregulation of PTPRJ expression, and in turn inhibition of cell growth and migration may present a previously unrecognized mechanism of chemoprevention by nutrients

ANIMAL & CELL MODELS

Cd148-deficient mouse platelets exhibited reduced collagen-mediated aggregation, secretion and spreading in association with reduced expression of GPVI and FcR gamma-chain and reduced tyrosine phosphorylation