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FLASH GENE

Symbol

PTPRJ

contributors: shn/npt/pgu - updated : 08-02-2016

HGNC name	protein tyrosine phosphatase, receptor type, J
HGNC id	9673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	190.28 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	PTPRJ gene has been mapped by fluorescence in situ hybridization to chromosome 11p11.2

regionally located

pter - D11S4117 - D11S1784 - PTPRJ - D11S1350 - D11S4183 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002843 25 - 7854 NP_002834 142 1337 - 2011 21543337 NM_001098503 9 - 3193 NP_001091973 53.3 539 - 2011 21543337

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus         Homo sapiens Nervous brain         Reproductive female system breast       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic       predominantly Connective bone       Epithelial       predominantly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet Homo sapiens Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular segment containing eight fibronectin type III repeats
	a single intracellular catalytic domain
	a transmembrane domain
	a single intracellular protein-tyrosine phosphatase (PTP) domain
	a short C-terminal tail containing three conserved tyrosine residues

HOMOLOGY

interspecies	ortholog to Ptprj, murine
	ortholog to PTPRJ, Pan troglodytes
	ortholog to Ptprj, Rattus norvegicus

Homologene

FAMILY	protein tyrosine phosphatase (PTP) family
	R3 family receptor-like PTP

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION

plasma membrane,junction

basic FUNCTION	may be contributing to the mechanism of contact inhibition of cell growth
	inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients
	may act as a tumor suppressor
	DEP-1 contributes to the contact inhibition of endothelial cell growth via dephosphorylation of vascular endothelial growth factor receptor 2
	positive regulator of VEGF mediated Src and Akt activation and endothelial cell survival
	implicated in cell growth and differentiation as well as in regulating phosphorylation of junctional proteins
	can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability
	enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases
	receptor-like protein-tyrosine phosphatase known to inhibit transduction of mitogenic signals in non-hematopoietic cells, and in in the hematopoietic lineage, inhibited signal transduction downstream of T cell receptor
	also plays an activating role via dephosphorylation of the inhibitory tyrosine in SRC
	negative regulator of TCR signaling, which is in apparent contradiction with data obtained from other leukocyte populations
	able to activate Src Family Kinases involved in TCR signal transduction
	may regulate differentiation of normal mammary epithelia and dysregulation of protein localisation may be associated with tumorigenesis
	plays a dominant role in activating SRC family kinases in platelets relative to PTPN1, and both PTPs are required for optimal platelet activation and aggregate formation under high arterial shear rates
	promotes airway hyperresponsiveness through SRC family kinases
	PTPRC and PTPRJ are transmembrane tyrosine phosphatases with large ectodomains that have activatory and inhibitory effects on TCR triggering
	positively regulates SRC family kinases and critical biological functions in endothelial and hematopoietic cells
	receptor-like protein tyrosine phosphatase mainly known for its antiproliferative and tumor-suppressive functions
	role as a mediator of an invasive cell program implicating SRC activation and the promotion of breast cancer progression

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

PTPRJ regulates negatively T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	VEGFR2
	may interact with and dephosphorylate PIK3CD when it is phosphorylated and modulate the magnitude of PI3K activity
	EGFR and PTPRJ physically interact at the cell surface and maintain bidirectional enzyme-substrate interactions, which are relevant to their respective oncogenic and tumor-suppressive functions
	interaction with occludin and TJP1 specific (occludin and TJP1 were dephosphorylated by PTPRJ but not the other phosphatases)
	PTP negatively regulating FLT3 phosphorylation and signaling
	PTPRJ is negatively regulating FLT3 signaling activity and its loss may contribute to but is not sufficient for leukemogenic cell transformation
	SDC2 is a novel ligand for the protein tyrosine phosphatase receptor PTPRJ
	functions as a receptor for THBS1 and mediates its inhibition of cell growth
	direct interaction of PTPRJ with the hematopoietic receptor-tyrosine kinase Fms-like tyrosine kinase-3 (FLT3)

cell & other

REGULATION

Other

phosphorylation of on threonine 1318 regulates SRC activation and endothelial cell permeability induced by vascular endothelial growth factor

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in colorectal, lung and breast cancer. tumoral     --low   may contribute to but is not sufficient for leukemogenic cell transformation (

Susceptibility

to breast cancer

Variant & Polymorphism

Candidate gene	candidate tumor suppressor in the colon epithelium
Marker
Therapy target	upregulation of PTPRJ expression, and in turn inhibition of cell growth and migration may present a previously unrecognized mechanism of chemoprevention by nutrients

ANIMAL & CELL MODELS

Cd148-deficient mouse platelets exhibited reduced collagen-mediated aggregation, secretion and spreading in association with reduced expression of GPVI and FcR gamma-chain and reduced tyrosine phosphorylation