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FLASH GENE
Symbol APC2 contributors: mct - updated : 27-06-2014
HGNC name adenomatosis polyposis coli 2
HGNC id 24036
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five copies of a 20 amino-acid motif able to bind beta-catenin and depleting the intracellular beta-catenin pool
    • HOMOLOGY
    interspecies homolog to murine Apc2
    intraspecies homolog to APC tumor suppressor gene
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • is distributed along microtubules in growth cones as well as axon shafts of retinal axons
    • basic FUNCTION
  • regulating the interaction of beta catenin with T cell specific transcription factor
  • potentially involved in WNT/wingless signaling pathway
  • involved in actin-associated events and may be influencing cell motility or adhesion
  • is distributed along microtubules in growth cones as well as axon shafts of retinal axons
  • has roles in both Wnt signaling and in actin and microtubule organization
  • cortical localization is required for the APC2 function in organizing actin, cortical localization is dispensable for its role in regulating Wnt signaling
  • plays a critical role in axonal projection through the regulation of microtubule stability
  • is an essential mediator of the cytoskeletal regulation at leading edges in response to extracellular signals
  • functions at the embryonic cortex with several protein partners, including AXIN1, to promote mitotic fidelity
  • protects genome stability by modulating mitotic fidelity through regulation of the cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EB3 for the stability and or extension of microtubules during neuritogenesis
  • APC2 binds DIAPH2 directly through a region of APC2 not previously shown to interact with DIAPH2-related formins
  • APC2 inhibitory activity of FBXO2 independent from its function as ubiquitin ligase, providing the basis for future studies of FBXO2 in aging and cancer
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • a lack of Apc2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum