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FLASH GENE

Symbol

APC2

contributors: mct - updated : 27-06-2014

HGNC name	adenomatosis polyposis coli 2
HGNC id	24036

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five copies of a 20 amino-acid motif able to bind beta-catenin and depleting the intracellular beta-catenin pool

HOMOLOGY

interspecies

homolog to murine Apc2

intraspecies

homolog to APC tumor suppressor gene

Homologene

FAMILY

CATEGORY

regulatory , tumor suppressor , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule
text	is distributed along microtubules in growth cones as well as axon shafts of retinal axons

basic FUNCTION	regulating the interaction of beta catenin with T cell specific transcription factor
	potentially involved in WNT/wingless signaling pathway
	involved in actin-associated events and may be influencing cell motility or adhesion
	is distributed along microtubules in growth cones as well as axon shafts of retinal axons
	has roles in both Wnt signaling and in actin and microtubule organization
	cortical localization is required for the APC2 function in organizing actin, cortical localization is dispensable for its role in regulating Wnt signaling
	plays a critical role in axonal projection through the regulation of microtubule stability
	is an essential mediator of the cytoskeletal regulation at leading edges in response to extracellular signals
	functions at the embryonic cortex with several protein partners, including AXIN1, to promote mitotic fidelity
	protects genome stability by modulating mitotic fidelity through regulation of the cytoskeleton

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	EB3 for the stability and or extension of microtubules during neuritogenesis
	APC2 binds DIAPH2 directly through a region of APC2 not previously shown to interact with DIAPH2-related formins
	APC2 inhibitory activity of FBXO2 independent from its function as ubiquitin ligase, providing the basis for future studies of FBXO2 in aging and cancer

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

a lack of Apc2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum