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FLASH GENE
Symbol APC2 contributors: mct - updated : 27-06-2014
HGNC name adenomatosis polyposis coli 2
HGNC id 24036
Location 19p13.3      Physical location : 1.450.147 - 1.473.243
Synonym name
  • adenomatous polyposis coli like
  • homolog to APC tumor suppressor gene
    • Synonym symbol(s) APCL
    DNA
    TYPE functioning gene
    STRUCTURE 26.97 kb     14 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 10151 - 2303 - 2011 21486956
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five copies of a 20 amino-acid motif able to bind beta-catenin and depleting the intracellular beta-catenin pool
    • HOMOLOGY
    interspecies homolog to murine Apc2
    intraspecies homolog to APC tumor suppressor gene
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • is distributed along microtubules in growth cones as well as axon shafts of retinal axons
    • basic FUNCTION
  • regulating the interaction of beta catenin with T cell specific transcription factor
  • potentially involved in WNT/wingless signaling pathway
  • involved in actin-associated events and may be influencing cell motility or adhesion
  • is distributed along microtubules in growth cones as well as axon shafts of retinal axons
  • has roles in both Wnt signaling and in actin and microtubule organization
  • cortical localization is required for the APC2 function in organizing actin, cortical localization is dispensable for its role in regulating Wnt signaling
  • plays a critical role in axonal projection through the regulation of microtubule stability
  • is an essential mediator of the cytoskeletal regulation at leading edges in response to extracellular signals
  • functions at the embryonic cortex with several protein partners, including AXIN1, to promote mitotic fidelity
  • protects genome stability by modulating mitotic fidelity through regulation of the cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EB3 for the stability and or extension of microtubules during neuritogenesis
  • APC2 binds DIAPH2 directly through a region of APC2 not previously shown to interact with DIAPH2-related formins
  • APC2 inhibitory activity of FBXO2 independent from its function as ubiquitin ligase, providing the basis for future studies of FBXO2 in aging and cancer
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • a lack of Apc2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum