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FLASH GENE
Symbol FZD1 contributors: shn - updated : 22-03-2017
HGNC name frizzled homolog 1 (Drosophila)
HGNC id 4038
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich domain
  • seven transmembrane segments (7TM)
  • a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies ortholog to Fzd1, Mus musculus
    ortholog to Fzd1, Rattus norvegicus
    ortholog to FZD1, Pan troglodytes
    ortholog to fzd1, Danio rerio
    Homologene
    FAMILY
  • G-protein coupled receptor Fz/Smo family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a receptors for Wnt signaling proteins
  • a functional partner for certain Wnts in inducing TCF dependent transcription
  • involvement of WNT1 and FZD1 in the pathogenesis and development of ALS
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • wingless-type MMTV integration site family member 3A, WNT3A and wingless-type MMTV integration site family member 5A, WNT5A
  • discs, large homolog 4, DLG4
  • lipoprotein receptor-1, LRP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of SOX9, WNT1, FZD1, and Ki-67 proteins occurred more frequently in human osteosarcoma tissues with an advanced clinical stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS