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FLASH GENE
Symbol FZD1 contributors: shn - updated : 22-03-2017
HGNC name frizzled homolog 1 (Drosophila)
HGNC id 4038
EXPRESSION
Rna function mRNAs expressed specifically in adult spiral ganglion neurons (
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Reproductivefemale systemplacenta  highly
 female systemovary  highly
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines HL60, HeLa, K562, MOLT-4, Raji, SW480, A549, G361
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich domain
  • seven transmembrane segments (7TM)
  • a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies ortholog to Fzd1, Mus musculus
    ortholog to Fzd1, Rattus norvegicus
    ortholog to FZD1, Pan troglodytes
    ortholog to fzd1, Danio rerio
    Homologene
    FAMILY
  • G-protein coupled receptor Fz/Smo family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a receptors for Wnt signaling proteins
  • a functional partner for certain Wnts in inducing TCF dependent transcription
  • involvement of WNT1 and FZD1 in the pathogenesis and development of ALS
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • wingless-type MMTV integration site family member 3A, WNT3A and wingless-type MMTV integration site family member 5A, WNT5A
  • discs, large homolog 4, DLG4
  • lipoprotein receptor-1, LRP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of SOX9, WNT1, FZD1, and Ki-67 proteins occurred more frequently in human osteosarcoma tissues with an advanced clinical stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS