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FLASH GENE

Symbol

FZD7

contributors: mct/ - updated : 10-04-2013

HGNC name	frizzled homolog 7 (Drosophila)
HGNC id	4045

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved N-terminal extracellular cysteine-rich domain that interacts with Wnts
	seven transmembrane segments (7TM)
	a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif

HOMOLOGY

interspecies

homolog to Drosophila frizzled polarity gene

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	exhibiting characteristics of a WNT receptor
	embryonic stem cell-specific surface antigen with a likely important role in the maintenance of embryonic stem cell self-renewal capacity
	activates the canonical Wnt pathway in colon cancer cells despite the presence of APC or CTNNB1 mutation
	playing a pivotal role in morphology transitions that are associated with colon tumor initiation and progression
	novel ES (embryonic stem) cell-specific surface antigen with a likely important role in the maintenance of ES cell self-renewal capacity
	may be involved in enhancement of survival, invasion and metastatic capabilities of colon cancer cells through non-canonical Wnt signalling pathways as well as the canonical pathway
	Wnt receptor most commonly upregulated in a variety of cancers
	plays an important role in stem cell biology and cancer development and progression
	FZD2 and FZD7 are competent to signal via the canonical pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ROR2/FZD7 receptor complex plays an important role in WNT5a/RAC1/AP-1 pathway by regulating polymerization of DVL2

INTERACTION

DNA

RNA

small molecule

protein	ROR2 can associate with FZD7 via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after WNT5A stimulation
	WNT-11/FZD7 controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin PCDH8 and C-cadherin via distinct FZD7 interaction domains
	genetic interactions between FZD2, FZD7 and VANGL2, DVL3 and WNT genes reflect interactions among different signaling pathways in developmental processes that are highly sensitive to perturbations in Frizzled signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary gastric and colorectal cancer tumoral     --low   in colon cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	promise as a biomarker for triple negative breast cancer
Therapy target
	System Type Disorder Pubmed cancer digestive colon FZD7-siRNA may be used as a therapeutic reagent for colorectal cancer cancer reproductive breast promise as a potential therapeutic target for triple negative breast cancer cancer     targeted inhibition of FZD7 represents a rational and promising new approach for cancer therapy

ANIMAL & CELL MODELS