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FLASH GENE
Symbol COX15 contributors: mct - updated : 29-03-2020
HGNC name COX15 homolog, cytochrome c oxidase assembly protein (yeast)
HGNC id 2263
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal mitochondrial leader peptide
  • five transmembrane domains
    • HOMOLOGY
    interspecies homolog to yeast Cox15
    Homologene
    FAMILY COX15/ctaA family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleoplasm
    text inner mitochondrial membrane in yeast
    basic FUNCTION
  • assembly of the backbone of c oxidase
  • playing an essential role in mitochondrial heme modification
  • plays a key role in the terminal component of the mitochondrial respiratory chain
  • increase in cell viability due to COX15 expression is consistent with its role in oxidative phosphorylation as an assembly factor for cytochrome c oxidase and its involvement removing apoptosis-inducing oxygen radicals
  • displays a role in cytochrome c oxidase assembly, which is independent of its functions as the heme a synthase
  • exhibits homotypic interactions, forming highly stable complexes dependent upon hydrophobic interactions
  • COX15 multimerization is important for heme a biosynthesis and/or transfer to maturing cytochrome c oxidase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the elctron transfer from reduced cytochrome c to molecule oxygen
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FHCM1 , COX15D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in a bilateral ocular persistent fetal vasculaturev
    constitutional     --over  
    COX 15 mRNA was significantly more abundant in the cerebral tissue of Alzheimer Disease patients
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP
  • c+1120C>T SNP in COX15 were significantly less represented in the patient with AD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS