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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CXCR3

contributors: mct - updated : 22-01-2016

HGNC name	chemokine (C-X-C motif) receptor 3
HGNC id	4540

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary melanoma tumoral       gain of function of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis

Susceptibility

to asthma to childhood inflammatory bowel disease

Variant & Polymorphism other	(rs2280964G>A) associated with Asthma susceptibility
	rs6817952 A variant is a risk allele for pediatric Crohn disease (CD) and ulcerative colitis (UC)

Candidate gene
Marker
Therapy target	targeting CXCR3 splice variants or the signaling pathways downstream of CXCR3 receptors may provide a therapeutic strategy for the prevention of Calcineurin inhibitors -mediated renal cancer progression

ANIMAL & CELL MODELS