| Symbol
| CXCR3
| contributors: mct - updated : 22-01-2016
|
| HGNC name
| chemokine (C-X-C motif) receptor 3
|
| HGNC id
| 4540
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in primary melanoma | | tumoral
|
|
|
| gain of function
|
of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis  | |
| Susceptibility
|
to asthma to childhood inflammatory bowel disease |
| Variant & Polymorphism
other
| (rs2280964G>A) associated with Asthma susceptibility |
|
rs6817952 A variant is a risk allele for pediatric Crohn disease (CD) and ulcerative colitis (UC) |
| 
|
Candidate gene
Marker
| Therapy target
| targeting CXCR3 splice variants or the signaling pathways downstream of CXCR3 receptors may provide a therapeutic strategy for the prevention of Calcineurin inhibitors -mediated renal cancer progression | |
| | |