Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CXCR3

contributors: mct - updated : 22-01-2016

HGNC name	chemokine (C-X-C motif) receptor 3
HGNC id	4540

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune natural killer Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	proximal 16 AAs residues of the N terminus required for CXCL10 and CXCL11 binding and activation but not CXCL9 activation
	seven transmembrane segment (7TM) receptor
	several extracellular loops
	extracellular domains required for ligand binding and activation
	C-terminus and third intracellular loop involved in receptor-mediated migration, adhesion and internalization in response to CXCL11

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Cxcr3 (83 pc)

intraspecies

homolog to IL8RA

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	chemokine receptor 3 for the interferon gamma inducible proteins INP10, MIG mediating a rapid induction of effector in T lymphocytes
	chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes
	playing an important role in effector T-cell and NK cell trafficking
	regulates the migration of Th1 lymphocytes and responds to three ligands: CXCL9, CXCL10, and CXCL11
	plays an important role in T cell trafficking and function
	role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation
	plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells
	promotes epidermal tumorigenesis likely through a T-cell-dependent induction of keratinocyte proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CXCL9-CXCR3 regulates Th1-associated immune pathways in liver

INTERACTION

DNA

RNA

small molecule

protein	binding CXCL9, CXCL10, CXCL11
	induced by uveitis antigens in lymphocytes and immature dendritic cells
	with its ligands, CXCL11, CXCL10, and CXCL9, play a major role in T-helper 1 (Th1)-dependent inflammatory responses
	receptor of CXCL11 (key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis)
	KLF2 negatively controls the ability of CD8 T cells to respond to the CXCR3 ligand CXCL10

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary melanoma tumoral       gain of function of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis

Susceptibility

to asthma to childhood inflammatory bowel disease

Variant & Polymorphism other	(rs2280964G>A) associated with Asthma susceptibility
	rs6817952 A variant is a risk allele for pediatric Crohn disease (CD) and ulcerative colitis (UC)

Candidate gene
Marker
Therapy target	targeting CXCR3 splice variants or the signaling pathways downstream of CXCR3 receptors may provide a therapeutic strategy for the prevention of Calcineurin inhibitors -mediated renal cancer progression

ANIMAL & CELL MODELS