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FLASH GENE
Symbol FAAH contributors: - updated : 01-09-2006
HGNC name fatty acid amide hydrolase
HGNC id 3553
Location 1p35-p34      Physical location : 46.859.938 - 46.879.520
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     15 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D1S441 - D1S443 - FAAH - D1S197 - D1S417 - cen
Authors Wan (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineadrenal gland   highly
Nervousbrain    
Reproductivefemale systemovary  highly
 male systemtestis  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal transmembrane domain, identified as an autonomously functioning homo-oligomerization domain
  • a FAAH amidase signature sequence
  • a SH3 binding domain
  • HOMOLOGY
    interspecies ortholog to murine Faah
    Homologene
    FAMILY amidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • fatty acid amide hydrolase, degrading neuromodulatory fatty acids such as oleamide and anandamide
  • primary catabolic regulator of fatty acid amide signaling in the nervous system
  • playing an important role in modulating a variety of neurobehavioral processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by progesterone, alone or additively with leptin, in T-cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to drug abuse
    Variant & Polymorphism SNP P129T increases the risk of drug abuse
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS