| basic FUNCTION
| involved with cellular proliferation and may play a role in leukemogenesis |
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has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis  |
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may serves as a recruiting factor for DNMTs and HDACs to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci |
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represses endogenous CDKN2A expression by recruiting HDAC to establish a repressive chromatin structure at the CDKN2A promoter, which in turn delays cell senescence |
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modulator of CpG methylation, crucial for the formation of normal heterochromatin and normal histone methylation |
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controls CpG methylation at selected HOX genes |
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essential for normal levels of DNA methylation in the mammalian genome |
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important for de novo DNA methylation events that accompany the establishment and differentiation of embryonic lineage cells |
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promotes binding of DNA methyltransferases and the EHMT2 complex to specific loci and facilitates developmentally programmed DNA methylation and stable gene silencing during lineage commitment and differentiation |
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major epigenetic regulator that is essential for DNA methylation and histone acetylation at repetitive elements |
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HELLS modulates CG methylation at all classes of repeat elements and is critical for repression of a subset of repeat elements |
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exerts epigenetic regulation at key regulators of neural stem cell fate ensuring adequate neural stem/progenitor cells (NSPCs) self-renewal and maintenance during development |
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is a chromatin remodeling factor that regulates DNA methylation and chromatin function in mammals |
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ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation |
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SWI2/SNF2 chromatin remodeling enzyme |
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is a key epigenetic driver of hepatocellular carcinoma |
