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FLASH GENE
Symbol EYA4 contributors: - updated : 26-01-2006
HGNC name eyes absent homolog 4 (Drosophila)
HGNC id 3522
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal large highly conserved domain of 271 AA,the eya homology domain
  • a basic segment followed by an alpha helical domain composed of four successive hepta repeats forming a leucine zipper
    • HOMOLOGY
    Homologene
    FAMILY
  • phosphatase subgroup of the haloacid dehalogenase-like (HAD)hydrolase superfamily
    • CATEGORY regulatory , transcription factor , receptor membrane tyrosine phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • transcriptional coactivator playing a role in embryonic and post natal development of mature organ of CORTI
  • participating directly in the modulation of cellular signaling through its phosphatase activity
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling sensory transduction/hearing , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SIX (EYA4/SIX mediated transcriptional regulation in heart function)
  • DAGH
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA10 , CMD1J
    related resource Hereditary Hearing Loss Homepage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS