basic FUNCTION
| actin-dependent regulator of chromatin structure |
|
possesses at least two interaction surfaces, one for NR3C1 and SMARCA4 and a second for SMARCC1 and SMARCC2 |
|
may provide another critical and direct link between nuclear receptors and the BRG1 complex that is required for promoter recruitment and subsequent chromatin remodeling |
|
directly interacts with the coactivator groove in the AR ligand-binding domain via its FxxFF motif, thereby selectively activating specific AR-driven promoters |
|
likely critical role for SMARCD1 in the coordinated regulation of hepatic circadian clock and energy metabolism in mammals |
|
likely key component of the transcriptional control in cardiac progenitors |
|
is a critical node integrating the circadian clock and vascular smooth muscle cells (VSMCs) physiological homeostasis |
|
EGFR, CALM3 and SMARCD1 play roles in bone and/or fat metabolism |
|
is both an activator and a repressor and is enriched at developmental regulators and its chromatin binding coincides with H3K27me3 |
|
potential role for SMARCD1 in restricting pluripotency and activating lineage pathways by regulating H3K27 methylation |
|
SMARCB1, SMARCD1 and SMARCE1 might act as novel pro-senescence factors in both normal and tumor human skin cells |
|
regulates the transcription of target genes through the alterations of chromatin structure |
|
dietary nutrient-associated impaired expression of SMARCD1 triggers likely cellular senescence and lipid accumulation |
|
functional redundancy between SMARCD1 and SMARCD3 in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance |
|
is required for normal memory, post-development, in adult neurons |
|
role of SMARCD1 in establishing proper cognitive functions |
|
SMARCD1, D2, D3 proteins are involved in the regulation of numerous hormone-dependent AR-driven genes and play an important, yet paradoxical, role in prostate carcinogenesis |