Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SMARCC2 contributors: npt/mct - updated : 30-01-2019
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
HGNC id 11105
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • chromatin organization modifier domain
  • a SANT domain, having DNA-binding activity and believed to function as a histone tail binding module
  • a highly conserved SWIRM (Swi3, Rsc8, and Moira) domain, interacting with DNA, binding di-nucleosome structures, and mediating specific protein-protein interactions
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae SWI/SNF
    intraspecies paralog to SMARCC1
    Homologene
    FAMILY
  • SMARCC family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text matrix associated
    basic FUNCTION
  • actin-dependent regulator of chromatin structure
  • intrinsic factor of glial radial cells and plays a crucial role in embryogenesis and corticogenesis, determining the mammalian body and cortical size
  • chromatin regulation by SMARCC2 controls cerebral cortical size and thickness
  • expression of SMARCA2 and SMARCC2 during reprogramming was regulated by JAK/STAT3 activity
  • involvement of SMARCC2-dependent chromatin remodeling in hippocampal neurogenesis and cognition, suggesing a specific role of adult neurogenesis in dentate gyrus (DG) in adaptive behavior
  • SMARCC2, SMARCC1 play essential roles in specification, olfactory neural stem cells (oNSCs) proliferation and olfactory receptor neurons (ORNs) maturation of developing olfactory epithelium
    • CELLULAR PROCESS nucleotide, chromatin organization
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the chromatin remodeling complex
  • subunit of the chromatin remodeling complex mSWI/SNF
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMARCD3 and SMARCC2 are required for proper BAF complex composition, and SMARCC2 loss leads to retention of SMARCA4 at cardiac precursors (CPs)-specific sites
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IDSDBA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS