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FLASH GENE
Symbol LOR contributors: mct - updated : 25-05-2011
HGNC name loricrin
HGNC id 6663
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentcornified cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three long glycine-serine-cysteine rich sequence domains, forming glycine loops
  • lysine and glutamine rich domains, involved in isodipeptide cross links
    • HOMOLOGY
    Homologene
    FAMILY
  • SPRR family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • major keratinocyte cell envelope protein
  • Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major protein constituent of the cornified cell enveloppe in stratum corneum
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by Sp1, c-Jun, an unidentified regulator, and the co-activator p300/CREB-binding protein
    inhibited by Th2 cytokines that inhibit expression of LOR and IVL through a STAT-6 dependent mechanism
    repressed by Sp3, CREB-1/CREMalpha/ATF-1, Jun B, and an AP2-like protein (termed the keratinocyte-specific repressor-1 (KSR-1))
    ASSOCIATED DISORDERS
    corresponding disease(s) KHM1 , PSEK1
    Susceptibility
    Variant & Polymorphism
    Candidate gene for PSORS4
    Marker
    Therapy target
    ANIMAL & CELL MODELS