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FLASH GENE

Symbol

HCN1

contributors: mct/npt - updated : 18-03-2019

HGNC name	hyperpolarization activated cyclic nucleotide-gated potassium channel 1
HGNC id	4845

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	absence of Hcn1 in Cngb1 knockout (KO) mice exacerbated photoreceptor degeneration
	mice lacking the pacemaker channel HCN1 display congenital Sinus node dysfunction (SND) characterized by bradycardia, sinus dysrhythmia, prolonged sinoatrial node recovery time, increased sinoatrial conduction time, and recurrent sinus pauses