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FLASH GENE
Symbol GIGYF1 contributors: mct - updated : 22-04-2008
HGNC name GRB10 interacting GYF protein 1
HGNC id 9126
Location 7q22      Physical location : 100.277.129 - 100.286.870
Synonym name
  • PERQ amino acid rich, with GYF domain 1
  • postmeiotic segregation increased 2-like 12
  • GYF domain containing 1
    • Synonym symbol(s) PMSR12, PMS2L12, PMSL12, PERQ1, GYF1, CDS2, PP3360
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 9.00 kb     24 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 6329 115 1035 - Szafranski (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GYF domain, binding proline-rich sequences, and interacting with the GRB10 proline-rich region
    • HOMOLOGY
    interspecies homolog to murine Perq1
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may acting cooperatively with GRB10 to regulate receptor signaling
    • CELLULAR PROCESS nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linked to insulin-like growth factor (IGF-I) receptors by the GRB10 adapter and modulating IGF-I signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS