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FLASH GENE

Symbol

PAX6

contributors: mct/shn - updated : 02-06-2017

HGNC name	paired box 6
HGNC id	8620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Pax6(+/-) mice display corneal abnormalities (
	overexpression of Pax6DeltaPD causes a severe microphthalmic phenotype in both wild-type and Pax6-deficient (Sey(/+)) mice in a dosage-dependent manner (
	homozygous mutant mice for Pax6 are characterized by markedly decreased pancreatic beta and delta cells and absent alpha cells
	Silencing the Pax6 gene with short interfering RNA resulted in an inhibited growth and an increased apoptosis of cultured human retinoblastoma cells (