basic FUNCTION
| large nucleotide exchange factor for the ADP-ribosylation factor |
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guanine nucleotide-exchange protein for ADP-ribosylation factor predominantly toured ARF6, putatively involved in retrograde trafficking |
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required for Golgi-localized, gamma-ear-containing, ADP ribosylation factor (Arf)-binding proteins (GGA) recruitment to Golgi membranes and plays a role in the proper processing and sorting of lysosomal cargo |
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required for COPI recruitment, Golgi subcompartmentalization, and cargo progression to the cell surface |
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regulates COPI membrane recruitment in the early secretory pathway |
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promotes the activation of ARF5 through replacement of GDP with GTP |
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GBF1 and ARF1 function in vesicular trafficking, lipid homoeostasis and organelle dynamics  |
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ARF1 small G protein and its activator GBF1 are important regulators of Golgi organization, maintaining its morphology and function  |
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is mainly involved in the formation of coatomer protein complex (COPI) vesicles, maintenance and function of the Golgi apparatus, and mitochondria migration and positioning  |
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protein plays an important yet unexplored role in neuronal development and maintenance  |
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GBF1 is a central player in molecular pathways that are necessary for Golgi apparatus (GA) maintenance, structure, and function  |